'There's a good reason people over 60 are not donor candidates for
bone marrow transplantation. The immune system ages and weakens with
time, making the elderly prone to life-threatening infection and other
maladies, and a UC San Francisco research team now has discovered a
reason why.
"We have found the cellular mechanism responsible for the inability of
blood-forming cells to maintain blood production over time in an old
organism, and have identified molecular defects that could be restored
for rejuvenation therapies," said Emmanuelle Passegué, PhD, a
professor of medicine and a member of the Eli and Edythe Broad Center
of Regeneration Medicine and Stem Cell Research at UCSF. Passegué, an
expert on the stem cells that give rise to the blood and immune
system, led a team that published the new findings online July 30,
2014 in the journal Nature.
http://www.eurekalert.org/pub_releases/2014-07/uoc--kta073014.php
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